Tylenol uses up the liver's stores of GLUTATHIONE. Glutathione is the body's most important ANTIOXIDANT. Glutathione, Tylenol & Your Health: What You Should Know Interleukin 4 deficiency protects mice from acetaminophen induced liver injury and inflammation by prevention of glutathione depletion Inflammation Research Springer Nature Link Acetaminophen C8H9NO2 CID 1983 PubChem Sex differences in glutathione metabolism and acetaminophen toxicity Silymarin prevents acetaminophen induced hepatotoxicity via up regulation of the glutathione conjugation capacity in mice ScienceDirect