Metabolic pathway for NAPQI formation and detoxification by conjugation Download Scientific Diagram Napqi hi res stock photography and images Alamy GSH reduces NAPQI, the metabolite responsible for hepatotoxicity in acetaminophen toxicity. Toxic doses increase oxidation into NAPQI, overwhelming glutathione. How does ethanol interfere with acetaminophen metabolism? Image: https: t.co 6EY9dIwLXY Tox and Hound Fellow Friday What Terror Hath NAPQI Wrought? Problem 2: N acetyl para benzoquinone (NAPQI) is an oxidized metabolite of acetaminophen formed in the liver. NAPQI is converted into an acetaminophen glutathione conjugate, a non toxic metabolite NAPQI Wikipedia
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napqi and glutathione Mechanisms of Hepatocyte Detoxification